The F/A-18C is mainly a change from the standard Acceleration F/A-18. It is more realistic, has less engine power because it was overpowered and the speedbrake issue has been solved. It features a very detailed HUD that has two selecable colors, ILS, NAV, and a very spectacular GUN mode which you can actually shoot with.
The F/A-18E from Vertical Reality Simulations is currently the best fighter aircraft on the market for FSX. It features the most realistic "Fly-By-Wire" system and can shoot anything from AIM-9X to AIM-7's. It can drop guided and unguided bombs and can fire guns. It can also drop chaff and flares, and has a tremendously good cockpit with almost everything clickable and working.